5-FU-induced Acute Leukoencephalopathy
نویسندگان
چکیده
منابع مشابه
Teaching NeuroImages: 5-FU-induced acute leukoencephalopathy.
A 55-year-old man with carcinoma sigmoid colon (fluorouracil [5-FU]: cumulative dose of 6,600 mg/m; and oxaliplatinum: 245 mg/m) presented with encephalopathy and pancerebellar involvement 2 weeks after receiving a third cycle of chemotherapy. Brain MRI showed diffusion restriction in bilateral deep white matter, cerebellar peduncles, and splenium of corpus callosum (figures 1 and 2) suggestive...
متن کامل5-Fluorouracil (5-FU) Induced Acute Toxic Leukoencephalopathy
This is a 57-year-old right-handed male with a history of locally advanced esophageal adenocarcinoma, who presented with confusion and speech changes. Patient received 5-Fluorouracil (5-FU) and cisplatin four days prior to presentation, which was complicated by very poor oral intake on day 2 of therapy. On the day of presentation, he was confused and his speech was slurred. The remainder of the...
متن کامل5-FU induced acute toxic leukoencephalopathy: early recognition and reversibility on DWI-MRI.
Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a...
متن کامل5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency.
Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnosed with partial deficiency of dihydropyrimidine dehydrogenase, an enzyme necessary for 5-FU catab...
متن کامل5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency
inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency Article abstract—Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnos...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2004
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.43.1009